I found the Kellondock et al article to be interesting due to the fact that it approached schizophrenia with focus on the D2 receptor. One of the theories behind the cause of schizophrenic symptoms was the role of dopamine expression. Since schizophrenia encompasses a wide range of symptoms, it can be that dopamine activity may not be the only factor but it is a promising area of research. Kellondock et al was able to explain how the overexpression of D2 receptors led to working memory failure. Their findings showed that increasing the number of receptors does correlate to the lack of working memory.
However much like how schizophrenia can be caused by different factors, I don’t believe Kellondock et al succeeded in proving that D2 overexpression can conclusively determine whether or not schizophrenia is present. Just like how there are multiple symptoms of schizophrenia, they may not be caused by the same type of factor. If only working memory deficits are seen, it can be a good model to see if D2 plays a role in the disorder. Kellondock et al does a decent job of convincing the readers that there is a correlation between the D2 and memory deficits but it does not encompass why other symptoms of schizophrenia occur.
Much like Yiu et al tried to identify a model for post traumatic stress disorder, Kellondock et al does a decent job of identifying what may cause one particular symptom of schizophrenia. Schizophrenia is a complex disorder that can take on different types of symptoms and therefore can't be completely understood using one model. I believe Kellondock et al is onto a good path especially in the terms of dopamine roles but it is not completely convincing. The testing done demonstrated the slight correlation of dopamine but the results were not completely significant to prove the intentions of the model. I believe the paper had potential but it should try to address other symptoms as well.
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